O/W型微乳对鱼腥草油增溶作用的研究
投稿时间:2009-06-16    责任编辑:  点此下载全文
引用本文:易红,高进,杨华.O/W型微乳对鱼腥草油增溶作用的研究[J].中国中药杂志,2010,35(1):49.
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作者中文名作者英文名单位中文名单位英文名E-Mail
易红 YI Hong 中国中医科学院 中药研究所,北京 100700 Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China  
高进 GAO Jin 中国中医科学院 中药研究所,北京 100700 Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China  
杨华 YANG Hua 中国中医科学院 中药研究所,北京 100700 Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China yanghua2796@sina.com 
基金项目:国家"十一五"科技支撑计划项目(2006BAI14B05);科技部"重大新药创制"科技重大专项(2009ZX09301-005-05);中国中医科学院自主选题项目(ZZ2006108)
中文摘要:目的: 研究O/W型微乳对鱼腥草油的增溶作用,确定鱼腥草油微乳处方。 方法 :通过滴定法制备的拟三元相图,绘制出增溶曲线,系统研究微乳对鱼腥草油增溶作用的影响,并比较胶体液与微乳液对鱼腥草油的增溶差异。 结果 :微乳辅料品种、用量对鱼腥草油增溶作用都有影响。确定的O/W型鱼腥草油微乳处方为中碳链三甘酯为油相,EL-35为表面活性剂,1,2-丙二醇为助表面活性剂,Km比为2 ∶ 1。 结论 :适宜的微乳处方可以增溶鱼腥草油,为进一步开发鱼腥草油微乳制剂提供研究基础。
中文关键词:鱼腥草油  微乳  增溶
 
Solubilization of O/W microemulsion for volatile oil from Houttuynia Cordra
Abstract:Objective : To study the solubilization of O/W microemulsion system for volatile oil from Houttuynia Cordra and determine the formulation of its microemulsion. Method : The solubilization curve was drawn from pseudo-ternary phase diagram plotted by using the method of titration. The microemulsion's effect on solubilization for volatile oil from Houttuynia Cordra was systematically studied and the difference solubilization effects between colloid fluid and microemulsion were compared. Result : Excipient varieties and amount of microemulsion had effects on solubilization for volatile oil from Houttuynia Cordra. The formulation of its microemulsion was determined and we chose medium-chain triglycerides as oil phase, polyoxyethylene castor oil EL-35 as surfactant,propylene glycol as cosurfactant and the surfactant to cosurfactant ratio was 2. Conclusion : Suitable microemulsion formulation can solubilize volatile oil from Houttuynia Cordra and it can provide research foundation for further development of microemulsion preparation for volatile oil from Houttuynia Cordra.
keywords:volatile oil from Houttuynia Cordra  microemulsion  solubilization
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