肿节风中黄酮苷类成分研究
投稿时间:2007-12-03    责任编辑:  点此下载全文
引用本文:黄明菊;曾光尧;谭健兵;李妍岚;谭桂山;周应军.肿节风中黄酮苷类成分研究[J].中国中药杂志,2008,33(14):1700.
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黄明菊;曾光尧;谭健兵;李妍岚;谭桂山;周应军
中文摘要:目的:研究中药肿节风的化学成分,为阐明其有效成分提供依据。方法:利用聚酰胺、Sephadex LH-20,Lipophilic sephadex LH-20柱色谱进行分离,根据化合物的理化性质和波谱数据(IR,UV,MS,1H-NMR,13C-NMR)鉴定其结构。结果:从肿节风水提取物中分离得到5个黄酮苷类和3个其他类化合物,分别鉴定为:山柰酚-3-O-β-D-葡萄糖醛酸苷(1),槲皮素-3-O-α-D-葡萄糖醛酸苷(2),槲皮素-3-O-β-D-葡萄糖醛酸甲酯(3),5,7,4′-三羟基-8-C-β-D-葡萄糖二氢黄酮碳苷(4),新落新妇苷(5),5-O-咖啡酰基-奎宁酸甲酯(6),3,4-二羟基苯甲酸(7),异秦皮啶(8)。结论:化合物1~6为首次从本属植物中得到,其中1~3为该属中首次发现的葡萄糖醛酸类化合物。
中文关键词:肿节风  化学成分  黄酮苷  葡萄糖醛酸
 
Studies on flavonoid glycosides of Sarcandra glabra
HUANG Ming-ju; ZENG Guang-yao; TAN Jian-bing; LI Yan-lan; TAN Gui-shan; ZHOU Ying-jun
Abstract:Objective: To in vestigate the chemical constituents of Sarcandra glabra and obtain a more comprehensive understanding on its effective components. Method: The constituents were isolated by various column chromatographic method and their structures were elucidated by physico-chemical properties and spectroscopic analysis. Result: Five flavonoid glycosides were isolated and identified as kaempferol-3-O-β-D-glucuronide (1), quercetin-3-O-α-D-glucuronide (2), quercetin-3-O-β-D-glucuronopyranoside methyl ester (3), 5, 7, 4′-trihydroxy-8-C-β-D-glucopyranosyl flavanone (4), neoastilbin (5), 5-O-caffeoylquinic acid methyl ester (6), 3, 4-dihydroxybenzoic acid (7), isofraxidin (8). Conclusion: Compounds 1-6 were isolated from the genus Sarcandra for the first time. The glucuroide compounds compounds 1-3, were first isolated from the genus Sarcandra.
keywords:Sarcandra glabra  chemical constitutes  flavonoid glycosides  glucuronide acid
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