复方丹参方主要活性成分网络药理学研究
投稿时间:2011-08-03    责任编辑:  点此下载全文
引用本文:李翔,吴磊宏,范骁辉,张伯礼,高秀梅,王毅,程翼宇.复方丹参方主要活性成分网络药理学研究[J].中国中药杂志,2011,36(21):2911.
DOI:10.4268/cjcmm20112102
摘要点击次数: 2795
全文下载次数: 1817
                    
作者中文名作者英文名单位中文名单位英文名E-Mail
李翔 LI Xiang 浙江大学 中药科学与工程学系, 浙江 杭州 310058 Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
吴磊宏 WU Leihong 浙江大学 中药科学与工程学系, 浙江 杭州 310058 Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
范骁辉 FAN Xiaohui 浙江大学 中药科学与工程学系, 浙江 杭州 310058 Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
张伯礼 ZHANG Boli 天津中医药大学 天津市现代中药省部共建国家重点实验室, 天津 300193 State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
高秀梅 GAO Xiumei 天津中医药大学 天津市现代中药省部共建国家重点实验室, 天津 300193 State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
王毅 WANG Yi 浙江大学 中药科学与工程学系, 浙江 杭州 310058 Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China mysky@zju.edu.cn 
程翼宇 CHENG Yiyu 浙江大学 中药科学与工程学系, 浙江 杭州 310058 Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China  
基金项目:国家自然科学基金重点项目(30830121);科技部国际合作项目(2009DFB03510)
中文摘要:目的: 采用网络药理学方法研究复方丹参方,探索其多成分-多靶点-多疾病相关关系。 方法: 针对方中丹参酮IIA、丹酚酸B、原儿茶醛、丹参素、隐丹参酮、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1、龙脑等9个活性成分,依据PubMed中相关文献知识构建多成分-基因网络,进而用OMIM数据库中的心血管相关疾病-基因关系数据,采用Cytoscape软件建立多成分-多基因-多疾病网络模型。 结果与结论: 网络分析表明,这9个活性成分可调控PPARG,ACE,KCNJ11,KCNQ1,ABCC8等42个心血管相关疾病基因表达,涉及糖尿病、高胰岛素型低血糖症等30种疾病,提示复方丹参方具有新的临床适应症研究前景。
中文关键词:网络药理学  复方丹参方  网络中药药理学  冠心病  糖尿病
 
Network pharmacology study on major active compounds of Fufang Danshen formula
Abstract:Objective: To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases. Method: Literature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone ⅡA, salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software. Result and Conclusion: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e.g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.
keywords:network pharmacology  Fufang Danshen formula  network traditional Chinese medicine pharmacology  coronary heart disease  diabetes mellitus
查看全文   下载PDF阅读器
相关阅读
评论
zuo-jiat you-jiat