生物黏附递药系统的研究进展及其在中药领域的应用
投稿时间:2017-09-06    责任编辑:  点此下载全文
引用本文:李鹏跃,杜守颖,陆洋,陈笑南.生物黏附递药系统的研究进展及其在中药领域的应用[J].中国中药杂志,2017,42(24):4687.
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作者中文名作者英文名单位中文名单位英文名E-Mail
李鹏跃 LI Peng-yue 北京中医药大学 中药学院, 北京 100102 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China  
杜守颖 DU Shou-ying 北京中医药大学 中药学院, 北京 100102 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China dushouying@263.net 
陆洋 LU Yang 北京中医药大学 中药学院, 北京 100102 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China  
陈笑南 CHEN Xiao-nan 北京中医药大学 中药学院, 北京 100102 School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China  
基金项目:国家"重大新药创制"科技重大专项(2014ZX09301306-008)
中文摘要:生物黏附递药系统是一类以具有生物黏附特性的高分子材料制备的释药系统。该类递药系统不仅能够延长药物在给药部位的滞留时间,提高药物的稳定性,促进药物的黏膜吸收,还能实现药物的靶向递药。随着高分子材料的不断发现和广泛应用,在过去30余年中,生物黏附制剂取得了长足的发展,研究者也尝试将这一技术引入中药制药领域。为了系统了解生物黏附制剂的发展现状,该文对其黏附机制、黏附材料、评价方法及其在中药领域的应用进行了综述,旨在为中药生物黏附制剂的进一步研究提供新的思路。
中文关键词:生物黏附递药系统  黏附机制  黏附材料  评价方法
 
Bio-adhesive drug delivery system and its application in traditional Chinese medicine
Abstract:Bio-adhesive drug delivery system (BDDS) is a novel drug delivery system, which can prolong the retention time of the preparation, improve the stability of the drug, and improve the mucosa absorption and the targeting of the drug. With the development of polymer materials over the past 30 years, BDDS made a great progress. This paper reviews the muco-adhesion theory, adhesive materials, and methods to evaluate muco-adhesive properties and applications in traditional Chinese medicine according to domestic and foreign literatures, in order to provide new ideas for further studies.
keywords:bio-adhesive drug delivery system  muco-adhesion theory  adhesive material  evaluation method
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